A medical device is adapted for at least partial implantation into a body
and includes first and second sections along the length of the device. A
first therapeutic agent is associated with the first section and a second
therapeutic agent is associated with the second section. The first
therapeutic agent can be one or more antiproliferative, such as
paclitaxel, a paclitaxel derivative, or a paclitaxel pro-drug,
anti-coagulant, antithrombotic, thrombolytic, fibrinolytic, or
combination thereof. The second therapeutic agent can be one or more
antimicrobials, such as one or more antibiotics. Each of the first and
second therapeutic agents can either be posited on one or more surfaces
of the respective section, or impregnated within the section. The device
can include a separator to space the first and second sections. A method
of making a medical device and a method of establishing access to a
vessel within a body are also provided.