The invention provides a method for producing a stabilized cell of interest, the method comprising providing a stem cell and/or a precursor cell of the cell of interest with a nucleic acid sequence which, when present in the cell of interest, is capable of stabilizing the cell of interest, providing a non-human animal with the stem cell and/or precursor cell, allowing generation of the cell of interest in said animal, and obtaining said cell of interest. The animal is preferably provided with a human stem cell and/or human precursor cell, allowing production of a human cell line.