An apparatus is disclosed for controlled neuromodulation. The apparatus includes a plurality of neural sensors, wherein each of the neural sensors is electrically connected to a separate signal conditioner. Each of the signal conditioners produces a neural sensor signal, which is analyzed by a separate threshold detector to produces a neural event signal when the neural sensor signal exceeds a threshold level associated with the threshold detector. Each of the threshold detectors is connected to a wireless transceiver and the wireless transceivers transmit the neural event signals to a processor. The processor analyzes the neural event signals and determines the presence or absence of a clinical brain state. The apparatus can be used to detect and control epileptic seizures.

 
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> Pyrazolo[1,5-a]pyridine derivatives or pharmaceutically acceptable salts thereof

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