The invention relates to synthetic leptin antagonists in which at least two amino acid residues of the sequence LDFI/S of the hydrophobic binding site at positions 39-42 of a leptin polypeptide sequence are substituted with different amino acid residues such that the site becomes less hydrophobic, and fragments of said leptin antagonists.

 
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> Sodium-independent transporter transporting small-sized neutral amino acid, gene thereof and method of analyzing transporter function by constructing fused proteins enabling the specification of the function

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