Methods and systems are provided for illuminating body part with LED system. A system includes a LED system, a medical instrument and a microprocessor. The LED system is adapted to generate a variable color radiation. The medical instrument is adapted for positioning the LED system in proximity to the body part to illuminate the body part. The microprocessor is adapted to control at least one electrical current supplied to the LED system to vary a color of the variable color radiation. Exemplary systems may be particularly configured and suitable for use in medical applications, including diagnostic, surgical, forensic, and therapeutic interventions.