A medicament having inhibitory activity against plasminogen activator
inhibitor-1, which comprises as an active ingredient a compound
represented by the following general formula (I) or a salt thereof:
wherein R.sup.1 and R.sup.2 represents an aromatic group which may be
substituted, W represents a group selected from the following connecting
group W-1: (wherein a bond at the left end binds to the carbon atom and
a bond at the right end binds to the nitrogen atom, X represents sulfur
atom or NH, Y represents oxygen atom or sulfur atom, R.sup.3 represents a
hydrocarbon group, hydroxy group, or carboxy group), Z represents a
single bond or a connecting group wherein a number of atoms in a main
chain is 1 to 3.