The present invention is a composition, methods of using that composition and kits including that composition, useful for reducing the size and improving the appearance of a closed wound wherein the composition comprises a therapeutically effective amount of a hydrophilic or hydrophobic carrier (or a mixture thereof), at least one matrix metalloproteinase (MMP) modulator in combination with one or more of the following pharmaceutically active agents: (a) cell cycle modulators; (b) inflammatory event modulators; (c) angiogenesis event modulators; (d) fibroblast migration agents; (e) fibroblast proliferation agents; (f) tissue remodeling correcting agents; (g) antimicrobial agents; (h)modulators of deposition of extra cellular matrix; (i) penetration enhancers; (j) antioxidants; (k) antipuritic agents; (l) fibrinolytic agents; (j) immunomodulators; (m) transcription modulating agents; (n) surface modulating agents; (o) growth factor inhibitors; and (p) anti-proliferative agents.