A spam manager (101) receives (201) at least one e-mail (106) addressed to a domain (103). The spam manager (101) performs (203) a signature based analysis of received e-mail (106) to determine whether received e-mail (106) includes at least one signature indicative of spam. Responsive to the spam manager (101) identifying e-mail (106) that does not include at least one signature indicative of spam and to a timeout period not having transpired from a time of receipt of the e-mail (106) by the spam manager (101), the spam manager (101) performs (205) at least one secondary analysis of the identified e-mail (106).

 
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> Albumin fusion proteins comprising GLP-1 polypeptides

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