An apparatus for handling printing plates contains at least one image-setting device and a frame that at least partially encloses the image-setting device. The image-setting device is decoupled from the frame via decoupling feet that stand on the floor through cutouts in the frame. If the image-setting device is decoupled from the frame, it is problematic or at least time-consuming to align the image-setting device and the frame with respect to one another. Alignment is particularly necessary when the frame contains further processing stations and transport systems. Simpler and more rapid alignment can be achieved by at least one guiding alignment element assisting the alignment of the image-setting device and of the frame with respect to one another.