The invention relates to compounds of formula (XVI): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof wherein Y.sub.2, Z, L.sub.1, R.sub.9, R.sub.10, m and u are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, immune disorders, and allergic disorders.

 
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> Phosphodiesterase 4 inhibitors

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