The present invention relates to compounds of the formula Q is selected
from the group consisting of G is selected from the group consisting of
alkyl, substituted alkyl, substituted or unsubstituted aryl, heterocyclo,
W is O or NR.sub.15; X is O or H,H; Y is selected from the group
consisting of O; H,OR.sub.16; OR.sub.17,OR.sub.17; NOR.sub.18;
H,NOR.sub.19; H,NR.sub.20R.sub.21; H,H; or CHR.sub.22; OR.sub.17OR.sub.17
can be a cyclic ketal; Z.sub.1 and Z.sub.2 are selected from the group
consisting of CH.sub.2, O, NR.sub.23, S, or SO.sub.2, wherein only one of
Z and Z.sub.2 is a heteroatom; B.sub.1 and B.sub.2 are selected from the
group consisting of OR.sub.24, or OCOR.sub.25, or
O.sub.2CNR.sub.26R.sub.27; when B.sub.1 is H and Y is OH, H they can form
a six-membered ring ketal or acetal; D is selected from the group
consisting of NR.sub.28R.sub.29, NR.sub.30COR.sub.31 or saturated
heterocycle; R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6,
R.sub.7, R.sub.13, R.sub.14, R.sub.18, R.sub.19, R.sub.20, R.sub.21,
R.sub.22, R.sub.26, and R.sub.27 are selected from the group H, alkyl,
substituted alkyl, or aryl and when R.sub.1 and R.sub.2 are alkyl can be
joined to form a cycloalkyl; R.sub.3 and R.sub.4 are alkyl can be joined
to form a cycloalkyl; R.sub.9, R.sub.10, R.sub.16, R.sub.17, R.sub.24,
R.sub.25, and R.sub.31 are selected from the group H, alkyl, or
substituted alkyl; R.sub.8, R.sub.11, R.sub.12, R.sub.28, R.sub.30,
R.sub.32, R.sub.33, and R.sub.30 are selected from the group consisting
of H, alkyl, substituted alkyl, aryl, substituted aryl, cycloalkyl, or
heterocyclo; R.sub.15, R.sub.23 and R.sub.29 are selected from the group
consisting of H, alkyl, substituted alkyl, aryl, substituted aryl,
cycloalkyl, heterocyclo, R.sub.32C.dbd.O, R.sub.33SO.sub.2, hydroxy,
O-alkyl or O-substituted alkyl, the pharmaceutically acceptable salts
thereof and any hydrates, solvates or geometric, optical and
stereoisomers thereof, with the proviso that compounds wherein W and X
are both O; and R.sub.1, R.sub.2, R.sub.7, are H; and R.sub.3, R.sub.4,
R.sub.6, are methyl; and R.sub.8, is H or methyl; and Z.sub.1, and
Z.sub.2, are CH.sub.2; and G is
1-methyl-2-(substituted-4-thiazolyl)ethenyl; and Q is as defined above
are excluded.
