A power supply system is disclosed. In one embodiment the power supply system includes a source of DC power that provides a DC bus voltage between a pair of DC bus terminals, and a power supply that receives power from the DC bus terminals and delivers power to a load. An output measurement circuit measures output parameters delivered by the power supply and provides a corresponding set of feedback signals. A feedback regulator connected receives the feedback signals and provides a feedback output signal operative to regulate the output of the power supply to achieve a desired voltage, current, or power level specified by a setpoint signal. An adaptive feedforward circuit connected to the feedback regulator and to the DC bus terminals provides a combined regulation signal to the power supply that minimizes perturbations in the output of the power supply due to DC bus ripple voltage.