In an embodiment, an evoked response of an electrode may be determined. The evoked response may be compared to other evoked responses to determine the location of the electrode. The evoked response may be measured during electrode implantation so that desired changes can be made and if electrodes are being implanted in both the right and left hemisphere, it can be determined that both electrodes are positioned in the same target in both the right and left hemisphere. The evoked responses may be used to determine if the stimulation target has functional connectivity with the treatment areas. Stimulation parameters for the electrodes may be determined in a closed-loop configuration and used to stimulation the electrodes in an open-loop configuration designed to reduce the probability of neurological events such as seizures.