The invention relates to 4-cyanopyrazole-3-carboxamide derivatives of formula (I): ##STR00001## in which R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8 are as described herein. Also disclosed and claimed are the method of preparation and therapeutic application of compound of formula (I).

 
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> Withanamide and withanolide compositions and method of use thereof

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