The present invention is directed to 1.alpha.,25-dihydroxyvitamin D3 mimics which modulate the vitamin D receptor (VDR). The invention is further directed to pharmaceutical compositions and methods for the treatment, prevention or amelioration of one or more symptoms of disease or disorder related to the activity of the vitamin D receptor using an effective amount of a compound of formula (I).

 
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> Topically applied circulation enhancing agent and skin and hair cosmetic and bath agent containing the same

~ 00380