An orthopedic brace is provided that is adapted for securing a wrist, hand and thumb. The brace includes a pad having proximal and distal edges, and first and second sides each comprising loop fastening material forming a generally continuous surface extending substantially the entirety of the corresponding side. The brace further includes a strap pod having an attaching portion and at least one strap, the attaching portion being defined by a region of a hook fastening material such that the attaching portion is removably securable to either side of the pad for placing the pad in a closed position. A thumb stay is disposed in a thumb stay pocket formed by the pad. A distal closure member extends from or near the distal edge of the pad, and defines a first extension depending from the pad, and an intermediate flap depending from the first extension. The intermediate flap is configured to extend about the thumb stay, and defines at least one strap securable to the first and second sides of the pad.