A method and apparatus for optically interrogating a particle comprising obtaining a plurality of optical interrogations from a plurality of orientations relative the particle. In one aspect, the particle is tumbled relative to optical interrogation direction and reflected or transmitted energy is collected and weight of one or several seeds is derived.

 
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> Method of structure-based drug design to create or improve modulators of IL-1 activity which bind to the interleukin-1 type 1 receptor

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