A system and method to administer a liquid agent into a body cavity of a patient is provided. One exemplary system comprises a lumen disposed into an airway of the patient and a valve assembly coupled to the lumen. The valve assembly comprises a body portion, a first port and a second port. A pump assembly for receiving the liquid agent is coupled to the valve assembly in a fluid tight relationship. The pump assembly provides the liquid to the lumen through the first port of the valve assembly. The liquid along with a portion of secretions generated by the patient are extracted through the lumen and flow out of said valve assembly through the second port for disposal responsive to a natural body function and/or a vacuum from a vacuum source. One exemplary method comprises the steps of disposing a lumen into the body cavity of the patient, the lumen comprising a fluid port; introducing the liquid agent into the body cavity through the fluid port; and extracting at least the liquid from the body cavity through the fluid port responsive to a natural body function and/or a vacuum from the vacuum source.