The subject invention concerns methods and compounds that have utility in the treatment of a condition associated with cyclooxygenase-2 mediated disorders. Compounds of particular interest are benzopyrans and their analogs defined by formula 1 ##STR00001## Wherein Z, X, R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are as described in the specification.

 
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> Interferon-.beta. variants and conjugates

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