Surprisingly, the present inventors have discovered that expression of TAT-044 protein in human patients is associated with cancer, and that the overexpressed protein is present in plasma membrane fractions. Thus, the present inventors have discovered that TAT-044 is associated with abnormal development and growth, and may be useful as a target for the identification of anti-cancer compounds, including antibodies for use in immunotherapy. Accordingly, the present invention provides methods for the identification of compounds that inhibit TAT-044 expression or activity, comprising: contacting a candidate compound with a TAT-044 and detecting the presence or absence of binding between said compound and said TAT-044, or detecting a change in TAT-044 expression or activity. Methods are also included for the identification of compounds that modulate TAT-044 expression or activity, comprising: administering a compound to a cell or cell population, and detecting a change in TAT-044 expression or activity. The methods of the invention are useful for the identification of anti-cancer compounds.

 
Web www.patentalert.com

> METHOD OF TREATING PAIN BY ADMINISTERING 24 HOUR ORAL OPIOID FORMULATIONS EXHIBITING RAPID RATE OF INITIAL RISE OF PLASMA DRUG LEVEL

~ 00370