The present invention relates to compounds, compositions, and methods for
the study, diagnosis, and treatment of traits, disease and conditions
that respond to the modulation of histone deacetylase (HDAC) gene
expression and/or activity. The present invention is also directed to
compounds, compositions, and methods relating to traits, diseases and
conditions that respond to the modulation of expression and/or activity
of genes involved in HDAC gene expression pathways or other cellular
processes that mediate the maintenance or development of such traits,
diseases and conditions. Specifically, the invention relates to double
stranded nucleic acid molecules including small nucleic acid molecules,
such as short interfering nucleic acid (siNA), short interfering RNA
(siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short
hairpin RNA (shRNA) molecules capable of mediating or that mediate RNA
interference (RNAi) against HDAC gene expression, including cocktails of
such small nucleic acid molecules and lipid nanoparticle (LNP)
formulations of such small nucleic acid molecules. The present invention
also relates to small nucleic acid molecules, such as siNA, siRNA, and
others that can inhibit the function of endogenous RNA molecules, such as
endogenous HDAC micro-RNA (miRNA) (e.g., miRNA inhibitors) or endogenous
HDAC short interfering RNA (siRNA), (e.g., siRNA inhibitors) or that can
inhibit the function of RISC (e.g., RISC inhibitors), to modulate HDAC
gene expression by interfering with the regulatory function of such
endogenous RNAs or proteins associated with such endogenous RNAs (e.g.,
RISC), including cocktails of such small nucleic acid molecules and lipid
nanoparticle (LNP) formulations of such small nucleic acid molecules.
Such small nucleic acid molecules are useful, for example, in providing
compositions for treatment of traits, diseases and conditions that can
respond to modulation of HDAC gene expression in a subject or organism,
such as cancer and other proliferative diseases or conditions that are
associated with HDAC gene expression or activity.