The present invention relates to compounds of the Formula ##STR00001## wherein R.sup.3, R.sup.5, R.sup.7, U, X, Y and Z are as defined. Compounds of the Formula I have activity inhibiting production of A.beta.-peptide. This invention also relates to pharmaceutical compositions and methods of treating diseases, for example, neurodegenerative diseases, e.g., Alzheimer's disease, in a mammal comprising compounds of the Formula I.

 
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> Codon-optimized .beta.-secretase and methods of refolding and processing

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