Methods are disclosed for sterilizing preparations containing albumin to
reduce the level of one or more active biological contaminants or
pathogens therein, such as viruses, bacteria (including inter- and
intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria,
chlamydia, rickettsias), yeasts, molds, fungi, prions or similar agents
responsible, alone or in combination, for TSEs and/or single or
multicellular parasites. These methods involve sterilizing preparations
containing albumin, such as plasma protein fractions, with irradiation.