A comprehensive system and method of rendering the mail safe for handling and for detecting and containing suspect pieces and which can be fitted or retrofitted into mail and package processing facilities with relative ease. The system of the present invention includes a mail tray initial neutralizing sub-system, a subsequent neutralizing sub-system, an analyzing (potentially hazardous material detection) sub-system, a diverting mechanism, and a receiving and holding sub-system (secure out-sort pocket). All components can be controlled or operate in conjunction with a processing/computing sub-system. A feeder sub-system provides the mail from trays, after initial neutralization by the initial neutralizing sub-system, to the mail transport system.