This invention relates to novel corosolic acid analogs of the formula I,
wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are as indicated
below in each of said analogs: 1. R.sub.1=COCH.sub.3,
R.sub.2=R.sub.3=R.sub.4=H, R.sub.5=COOH or R.sub.1, =R.sub.3=R.sub.4=H,
R.sub.2=COCH.sub.3, R.sub.5=COOH 2. R.sub.1=R.sub.2=COCH.sub.3,
R.sub.3=R.sub.4=H, R5=COOH 3. R.sub.1=COC.sub.5H.sub.4N,
R.sub.2=R.sub.3=R.sub.4=H, R.sub.5=COOH 4.
R.sub.1=COCH.sub.2NH.sub.2.HC.sub.1, R.sub.2=R.sub.3=R.sub.4=H,
R.sub.5=COOH 5. R.sub.1=COCH.sub.2(CH.sub.3)NH.sub.2.HC.sub.1,
R.sub.2=R.sub.3=R.sub.4=H, R.sub.5=COOH 6.
R.sub.1=COCH:CHC.sub.6H.sub.2(OCH.sub.3).sub.3,
R.sub.2=R.sub.3=R.sub.4=H, R.sub.5=COOCH.sub.3 7. R.sub.1 &
R.sub.2=S0.sub.2, R.sub.3=R.sub.4=H, R.sub.5=COOH 8.
R.sub.1=R.sub.2=R.sub.3=R.sub.4=H, R.sub.5=CONH.sub.2 9.
R.sub.1=R.sub.2=R.sub.3=R.sub.4=H, R.sub.5=CONHC.sub.6H.sub.5 10.
R.sub.1=R.sub.2=R.sub.3=R.sub.4=H, R.sub.5=CONHCH.sub.2CH.sub.2NH.sub.2
11. R.sub.1=R.sub.2=R.sub.3=R.sub.4=H, R.sub.5=CON(CH2CH.sub.2).sub.2NH
12. R.sub.1=R.sub.2=R.sub.3=R.sub.4=H, R.sub.5=CONHCH.sub.2CH.sub.20H 13.
R.sub.1=R.sub.2=R.sub.3=R.sub.4=H, R.sub.5=COOCH.sub.3 14.
R.sub.1=R.sub.2=COCH.sub.3, R.sub.3=R.sub.4=H, R.sub.5=COOCH.sub.3 15.
R.sub.1=R.sub.2=H, R.sub.3 & R.sub.4=0, R.sub.5=COOCH.sub.3 16.
R.sub.1=R.sub.2=COCH.sub.3, R.sub.3 & R.sub.4=0, R.sub.5=COOCH.sub.3 17.
R.sub.1=R.sub.2=H, R.sub.3 & R.sub.4=0, R.sub.5=COOH 18.
R.sub.1=R.sub.2=COCH.sub.3, R.sub.3 & R.sub.4=0, R.sub.5=COOH 19. R.sub.1
& R.sub.2=S0.sub.2, R.sub.3 & R.sub.4=0, R.sub.5=COOH 20.
R.sub.1=R.sub.2=H, R.sub.3 & R.sub.4=0, R.sub.5=CONH.sub.2 21.
R.sub.1=R.sub.2=R.sub.3=H, R.sub.4=OH, R.sub.5=CONH.sub.2 22.
R.sub.1=R.sub.2=R.sub.3=H, R.sub.4=OH, R.sub.5=COOCH.sub.3 23.
R.sub.1=R.sub.2=R.sub.3=R.sub.4=H, R.sub.5=CH.sub.20H 24.
R.sub.1=R.sub.2=R.sub.3=R.sub.4=H, R.sub.5=CHO 25.
R.sub.1=R.sub.2=R.sub.3=R.sub.4=H,
R.sub.5=COOCOC.sub.6H.sub.2(OCH.sub.3).sub.3 26.
R.sub.1=R.sub.2=R.sub.3=H, R.sub.4 & R.sub.5=OCO. These compounds exhibit
good hypoglycemic and 5-lipoxygenase inhibitory activities. They also
inhibit tumour growth. Pharmaceutical compositions containing known
adjutants and the title compound are also within the scope of this
invention.
