A method for localization and generation of short critical sequence uses an automatic test equipment to test an electronic device (e.g., memory device) by circuit simulation to localize and re-generate a very short critical sequence from a set of long worst-case pattern. The method includes defining a failure mechanism condition for search and localization process and re-production of the short critical sequence based on a mutation process from the critical sequence detected from a step (I) phase and number of pattern defined in population using a genetic algorithm step (II) phase.