A method for treating selected tissue, including exposing the selected bone or tissue to laser light having a wavelength between approximately 600 and 1400 nm, and maintaining such exposure of the selected tissue or bone to the laser light for a period of time sufficient to deliver a laser light dosage of at least 7 Joules/cm.sup.2 per treatment and maintaining such exposure for a period of time sufficient to deliver a laser light dosage of at least 1500 Joules per treatment within a 24 hour period of time. The method also includes upcollimating the laser light such that the laser delivers to the selected tissue a substantially coherent beam of laser light having a cross-sectional area of at least 2 cm.sup.2, and, further, delivering the laser light to a depth of at least 5 mm in the selected tissue.

 
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> METHODS AND COMPOSITIONS FOR TARGETING POLYUBIQUITIN

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