A method and system for configuration of the E-DCH is disclosed. The method and system for configuration of the E-DCH includes transmitting by a Serving Radio Network Controller (SRNC) RRC messages with an Added or Reconfigured UL TrCH information for configuration of MAC-d flow list to an user equipment (UE). The UE receives the RRC messages and confirms that a need exists to configure the MAC-d flow for the E-DCH. The UE performs the configuration process based on the RRC messages. The MAC-d flow list includes multiple MAC-d flow configuration messages.