A method and apparatus using photostimulation to treat or pretreat a
sample site prior to analyte property estimation is presented. More
particularly, photonic-stimulation at and/or near at least one sample
site is used to enhance perfusion of the sample site leading to reduced
errors associated with sampling. This allows an analyte property
determination in well perfused regions of the body while sampling at a
more convenient less well perfused region of the body.