A method and apparatus using photostimulation to treat or pretreat a sample site prior to analyte property estimation is presented. More particularly, photonic-stimulation at and/or near at least one sample site is used to enhance perfusion of the sample site leading to reduced errors associated with sampling. This allows an analyte property determination in well perfused regions of the body while sampling at a more convenient less well perfused region of the body.

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> Intragastric space filler and methods of manufacture

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