What is provided is an agent for the prevention or treatment of septicemia caused by the infection of microorganism. The agent for the prevention and/or treatment of septicemia caused by the infection of microorganism has (1) a soybean extract or soybean fermented product as an effective; (2) or isoflavone as an effective component. Also, (3) a food and drink, medicine, or cosmetic has the agent according to (1) or (2). The agent has a high suppressing activity of the abnormal production of TNF-.alpha. is useful in the fields of medicines, cosmetics and foods, especially for the profundus mycosis patient.