Disclosed are compounds of the formula or a pharmaceutically acceptable salt thereof, wherein M.sup.1 is M.sup.2 is N; X is a bond, optionally substituted alkylene, alkenylene, --O--, --CH.sub.2N(R.sup.12)--, --N(R.sup.12)CH.sub.2--, --N(R.sup.12)--, --NHC(O)--, --OCH.sub.2--, --CH.sub.2O--, or --S(O).sub.0-2--; and Y is --(CH.sub.2).sub.1-2--, --C(.dbd.O)--, --C(.dbd.NOR.sup.13)-- or --SO.sub.0-2--; or M.sup.1 is N; M.sup.2 is N or CH; X is a bond, alkylene, alkenylene, --C(O)--, --NHC(O)--, --OC(O)-- or --S(O).sub.1-2--; Y is --(CH.sub.2).sub.1-2--, --C(.dbd.O)-- or --SO.sub.0-2--; and when M.sup.2 is CH, Y is also Y is --O-- or --C(.dbd.NOR.sup.13)--; Z is a bond or optionally substituted alkylene or alkenylene; U and W are CH, or one is CH and one is N; R.sup.1 is optionally substituted alkyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heterocycloalkyl; R.sup.2 is optionally substituted alkyl, alkenyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl or heterocycloalkyl; and the remaining variables are as defined in the specification; and compositions and methods of treating obesity, metabolic syndrome and a cognition deficit disorder, alone or in combination with other agents.