Compounds of the formula ##STR00001## wherein: X is selected from the
group consisting of trihalomethyl, C.sub.1-C.sub.6 alkyl, and a group of
formula II: ##STR00002## wherein: R.sub.3 and R.sub.4 are
independently selected from the group consisting of hydrogen; halogen;
hydroxyl; nitro; C.sub.1-C.sub.6 alkyl; C.sub.1-C.sub.6 alkoxy; carboxy;
C.sub.1-C.sub.6 trihaloalkyl; and cyano; Z is selected from the group
consisting of substituted and unsubstituted aryl; or a pharmaceutically
acceptable salt thereof. The compounds are inhibitors of cyclooxygenase-2
activity. They are useful for treating cyclooxygenase-mediated disorders,
including, for example, inflamation, neoplastic disorders and
angiogenesis-mediated disorders.