A kind of ozone disinfecting non-cordless mouse that is installed with an internal ozone generator module, which is connected to the power of the USB (Universal Serial Bus) plug, such that the ozone generator can produce ozone gas during use of the mouse. The gas is dispelled through a suitable port in the carapace of the mouse, and can disinfect the mouse or its surrounding area, and disinfect or clean the surrounding air. The creation also includes an ozone disinfecting cordless mouse, in which an ozone generator module is installed in the interior of the receiver or recharger outlet of the mouse. This ozone generator module is powered by the existing power supply of the receiver or recharger outlet, and can produce ozone gas when the cordless mouse is inserted into the cradle of the receiver or recharger outlet. The resulting ozone gas is then dispelled through a suitable vent, and can disinfect the mouse or its surrounding area, and disinfect or clean the surrounding area.