A composition containing at least one NSAID formulated for topical administration to a mucous membrane and/or skin for prophylactic or symptomatic therapy. The composition may also contain an anti-irritant such as a non-nutritive sweetener, which improves compliance when applied to an oral or nasal mucous membrane. The composition may also contain a metalloproteinase inhibitor such as a tetracycline class compound at a neutral pH. The composition may be used for patients having or at risk for developing symptoms of viral infection such as cold sores, canker sores, or shingles, or for treatment of rashes due to allergies.