A method, system and computer program product for generating an electronic bill having optimized insurance claim items based on an insurance carrier of a patient are provided. The method includes receiving insurance carrier data which identifies a patient's insurance carrier and patient data which identifies a patient. The method also includes receiving treatment data which identifies a drug administered to the patient and a procedure performed on the patient on a date of service. The treatment data is processed to obtain nurse documentation, such as treatment and/or flow sheets. An electronic bill is automatically generated having optimized reimbursable insurance claim items including predetermined codes based on the treatment data and the insurance carrier data to facilitate approval of the bill by the insurance carrier.