The present invention provides an apparatus, system and method for removal of interference due to multi-path for multiple transmit antennas (hereinafter referred to as MTA-MPIC) for High Speed Downlink Packet Access (HSDPA) encoded for transmit diversity, such as Space-Time Transmit Diversity (STTD). For a single receive antenna, the signal is received (25) and each multi-path delayed signal is demodulated (21). The demodulation can include long code removal and despreading. Subsequently, each demodulated signal is received by the RAKE receiver (22) for determining the channel estimate and channel normalization for the total HSDPA signal, and for computing space-time decoding for the HSDPA signal. Following the space-time decoding, a data decision is made (23). Next, reconstructed interference signals are generated (24) and combined with the received signal (25). For other user signals, an interference estimate is made from the despreader (322) outputs without applying the RAKE/space-time coding operations.