The present invention relates to non-invasive and minimally invasive
techniques for evaluating the physical state of a subject, including
diagnosing a disease, disorder, or physical state of the subject,
determining the prognosis of the subject, determining a subject's
susceptibility for a disease, disorder, or physical state and
determining, developing and monitoring treatment for the same. The
invention also relates to identifying genetic alterations contributing
to, or susceptibility for, development of a disease, disorder, or
physical state, and for diagnosis, prognosis and treatment of the
disease, disorder, or physical state.