The present invention relates to methods for producing propylene glycol monoesters (PGMEs). A method comprises contacting a fatty acid material with a lipase to form a first composition, contacting the first composition with propylene glycol to form a second composition, and heating the second composition, wherein a PGME composition is produced. The present methods yield between about 40% to about 70% PGMEs or greater, and less than about 15% propylene glycol diester.