Nucleotide triphosphate probes containing a molecular and/or atomic tag on a a .gamma. and/or .beta. phosphate group and/or a base moiety having a detectable property are disclosed, and kits and method for using the tagged nucleotides in sequencing reactions and various assay. Also, phosphate and polyphosphate molecular fidelity altering agents are disclosed.

 
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> 4-trifluoromethylpyrazolyl-substituted pyridines and pyrimidines

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