Compounds of formula (I): wherein when m is 0 to 4 R1 is selected from C1
6alkyl, C3 7cycloalkyl, C2 6alkenyl, --SO2NR4R5, --CONR4R5 and --COOR4;
and when m is 2 to 4 R1 is additionally selected from C1 6alkoxy,
hydroxy, NR4R5, --NR4SO2R5, --NR4SOR5, --NR4COR5, and --NR4CONR4R5; R2 is
selected from hydrogen, C1 6alkyl and --(CH2)n-C3 7cycloalkyl; R3 is the
group --CO--NH--(CH2)p-R6; U is selected from methyl and halogen; W is
selected from methyl and chlorine; V and Y are each selected
independently from hydrogen, methyl and halogen; m is selected from 0, 1,
2, 3 and 4 wherein each carbon atom of the resulting carbon chain may be
optionally substituted with one or two groups selected independently from
C1 6alkyl; n is selected from 0, 1, 2 and 3; p and r are independently
selected from 0, 1 and 2; s is selected from 0, 1 and 2; or
pharmaceutically acceptable salts or solvates thereof, and their use as
pharmaceuticals, particularly as p38 kinase inhibitors ##STR00001##