The present invention provides compounds of Formula I ##STR00001## wherein W, Q, E, D, R.sup.6, R.sup.7, R.sup.8, Y, K, R.sup.9, R.sup.10, R.sup.12, G, and the double bond denoted "*" have any of the values defined therefore in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cardiovascular diseases, and cancers. Also provided are pharmaceutical compositions comprising one or more compounds of Formula I.