Nucleotide sequences coding signal transduction components in durable and broad-range resistance strategies based on plant defense. The invention relates to nucleotide sequences derived from a plant genorne, capable of encoding a polypeptide product which can be activated as a signaling molecule in the signal transduction pathway of resistance to a plant pathogen which resistance results from the interaction between polypeptide products encoded by a resistance gene and elicitors encoded by an avirulence gene in said soil pant pathogen wherein the polypeptide product encoded by the nucleotide sequence interacts with a polypeplide product encoded by said resistance gene. The invention further relates to the use of these sequences and/or polypeptide products in the establishment of durable and broad range resistance strategies based on plant defense.