A method for providing a therapeutic effect to a treatment site within a
patient's vasculature comprises positioning a catheter at the treatment
site. The catheter includes a heating element and a fluid delivery lumen
that is coupled to an exit port within a distal region of the catheter.
The method further comprises passing the therapeutic compound through the
delivery lumen and the exit port at a flow rate. The heated therapeutic
compound is provided to the treatment site. The method further comprises
exposing at least a portion of the treatment site and at least a portion
of the delivered heated therapeutic compound to ultrasonic energy
generated by the ultrasound radiating member.