A transdermal or transmucosal drug delivery device excellent in terms of drug permeability and skin irritability and capable of reducing power consumption, is disclosed. An output control circuit (4) of an energization pattern controller (1) supplies a combined energization of pulse depolarized type energization and at least one of direct current type energization and pulse energization between an anode-side device (5) and a cathode-side device (6) of iontophoresis. The details of combination of energization in the output control circuit (4) is determined based on external setting of the energization pattern controller (1) or internal storage information.

 
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> Production of functional proteins: balance of shear stress and gravity

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