A system and method for measuring and analyzing motility within a body
lumen such as the gastrointestinal (GI) tract, where an in vivo imaging
device such as a capsule captures images and transmits the images to a
processor, which calculates the motility of the device based on
comparison of the images. Preferably, the processor compares the
intensity of pairs of images or of elements of pairs of images, generates
a variance for the compared images, and calculates the motility of the
imaging device from the variances. The motility data may be presented to
a user in various manners; for example, a plot of motility over time may
be generated, or indications of low motility may be presented to the user
of the system.