Method and systems for neuromodulating vagus nerve(s) to provide therapy for neurological and neuropsychiatric disorders comprises implantable and external components. The pulsed electrical stimulation to vagus nerve(s) is used for disorders such as epilepsy, depression, anxiety disorders, neurogenic pain, compulsive eating disorders, obesity, dementia including Alzheimer's disease, and migraines. The pulsed electrical pulses to vagus nerve(s) may be provided using various forms of implanted pulse generators or various forms of implanted stimulus-receiver used with an external stimulator. The external components such as the programmer may communicate with the implanted pulse generator (IPG) utilizing magnetic inductive coupling or via wireless telemetry. Further, the external components such as the programmer or external stimulator may also comprise circuitry for networking with remote computers. The remote telemetry circuitry therefore allows for interrogation or programming of implanted device, from a remote location over a wide area network.

 
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> Process for the preparation of 1,2,3,4,8,9,10, 10a-octahydro-7bH-cyclopenta[b][1,4]diazepino-[6,7,1-hi]indole derivatives

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