A soybean cultivar designated CL722114 with high yield potential and tolerance to Roundup.TM. herbicide, further including the plants and seeds of the cultivar CL722114, methods for producing a soybean plant by crossing the cultivar CL722114 with itself or another soybean plant. The invention also relates to soybean cultivar CL722114 further comprising one or more single gene traits, and to methods of producing a soybean having such traits by introgression, transformation or mutagenesis. The invention also includes using the soybean cultivar CL722114 to produce other soybean cultivars, breeding lines, and progeny.