The present invention relates to the pharmaceutical composition comprising mainly the guaiacol family compound and the syringol family compounds, extracted from natural plant vinegar. The present invention provides that pharmaceutical compositions has effects of treating oxidative toxicity, regulating blood glucose level, improving blood flow, treating hangover and treating atopic dermatitis as well as the safe composition to be free from acute toxicity, subacute toxicity etc . . . The pharmaceutical composition of the present invention can be used as an agent or an ingredient of health functional food.