A system and method for polygon-smoothing in texture-based volume rendering is provided. The method comprises the steps of: downsizing a slice polygon and determining boundary polygons around the downsized slice polygon using a smoothing factor, wherein the downsized slice polygon comprises first vertices and the boundary polygons comprise second vertices; generating a falloff ramp between the first vertices of the downsized slice polygon and the second vertices of the boundary polygons; and rendering the downsized slice polygon with texture-based volume rendering and the boundary polygons with texture-based volume rendering and the falloff ramp.