The present invention relates to a multimode communication device having an automatic call-back setting mechanism that includes a first wireless communication module for transmitting a first radio frequency signal and having a decision process; a second wireless communication module coupled to the first wireless communication module for transmitting a second radio frequency signal. If the first wireless communication module receives an incoming call signal of a communication system, the determination process will determine whether or not to terminate the incoming call signal and the second wireless communication module makes a call back to the communication system. The invention also discloses a method for automatically setting the call-back mechanism and a method for setting a man-machine interface for automatically setting a call-back mechanism.